Key result
DOX/ATRA-NDs combined with ultrasound induced more tumor cell apoptosis and greater tumor growth inhibition compared with unmodified chemotherapeutics in liver and breast tumor models.
Why the study?
Does ultrasound-enhanced delivery of DOX/ATRA-loaded nanodiamonds improve tumor cell apoptosis and growth inhibition in liver and breast tumor models compared to unmodified chemotherapeutics?
Does ultrasound-enhanced delivery of DOX/ATRA-loaded nanodiamonds improve tumor cell apoptosis and growth inhibition in liver and breast tumor models compared to unmodified chemotherapeutics?
Ultrasound-enhanced delivery of DOX/ATRA-loaded nanodiamonds improves tumor cell apoptosis and growth inhibition in preclinical liver and breast tumor models.
Should not yet alter oncology practice; hypothesis-generating for EPR-targeted nanodrug co-delivery.
AIM: To build up a combined therapy strategy to address limitations of the enhanced permeability and retention (EPR) effect and improve the efficiency of tumor therapy. MATERIALS & METHODS: A pH-sensitive nanocomplex for co-delivery of doxorubicin (DOX) and all-trans retinoic acid (ATRA) was developed based on nanodiamonds (DOX/ATRA-NDs) to enhance intracellular retention of drugs. Meanwhile, ultrasound was employed to enhance tumor vascular penetration of DOX-ATRA-NDs. RESULTS: . Comparing with unmodified chemotherapeutics, the combined therapy induced more tumor cells apoptosis and greater tumor growth inhibition in both liver and breast tumor models. CONCLUSION: DOX-ATRA-NDs demonstrate great potential in clinical applications.
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Li et al. (2018) studied Liver and breast tumor models. DOX/ATRA-NDs combined with ultrasound vs. Unmodified chemotherapeutics was evaluated on Tumor cells apoptosis and tumor growth inhibition. DOX/ATRA-NDs combined with ultrasound induced more tumor cell apoptosis and greater tumor growth inhibition compared with unmodified chemotherapeutics in liver and breast tumor models.
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