Household cleaning agents impact on pediatric asthma: a systematic review and meta-analysis

Background Household cleaning agents promote hygiene along with causing respiratory effects, especially pediatric asthma. This systematic review quantified the association between exposure to household cleaning agents and pediatric asthma.Method Five databases were searched. Data were analyzed qualitatively and quantitatively. RevMan 5.4 calculated odds ratios (OR) with 95% confidence intervals (CI), and a funnel plot assessed publication bias. The Mixed Methods Appraisal Tool (MMAT) and GRADE framework assessed methodological quality and certainty respectively.Results Sixteen studies met the eligibility criteria. Meta-analysis showed a significant association between the use of household cleaning agents and pediatric asthma (OR 2.90 (95% CI: 2.13–3.95; p < 0.01, I2 = 98%). Exposure stages also showed significant (p < 0.01) association with household cleaning agents (OR 2.92 (95% CI: 2.12–4.03, I2 = 98%). No publication bias or high risk of bias was found.Conclusion A strong association between exposure to household cleaning agents and an increased risk of pediatric asthma was found. .