Key result
Ultrasonic backscatter analysis of human myocardium successfully detected a progressive transmural shift in fiber orientation of 9.2 degrees/mm, concordant with histologic measurements.
Why the study?
Can ultrasonic integrated backscatter accurately characterize the transmural shift of myofiber alignment in human ventricular myocardium compared to histologic analysis?
Can ultrasonic integrated backscatter accurately characterize the transmural shift of myofiber alignment in human ventricular myocardium compared to histologic analysis?
Absolute Event Rate: 9.2% vs 7.9%
Human myocardium manifests anisotropy of ultrasonic scattering that can accurately characterize intramural fiber alignment and three-dimensional organization, closely matching histologic measurements.
No takes yet. Share an insight, caveat, or question.
May enable noninvasive fiber mapping; leaves open in vivo validation before clinical use.
Wickline et al. (1991) studied Normal regions of explanted hearts with ischemic cardiomyopathy (n=6). Ultrasonic backscatter vs. Histologic analysis was evaluated on Transmural shift in fiber orientation (degrees/mm). Ultrasonic backscatter analysis of human myocardium successfully detected a progressive transmural shift in fiber orientation of 9.2 degrees/mm, concordant with histologic measurements.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: