Key result
Elevated levels of Lp-PLA2 mass in the highest quartile were independently associated with an increased prevalence of cognitive impairment compared to the lowest quartile (OR 4.882).
Why the study?
Is higher serum Lp-PLA2 mass associated with an increased prevalence of cognitive impairment in Chinese adults?
Cross-Sectional (n=1,374)
Is higher serum Lp-PLA2 mass associated with an increased prevalence of cognitive impairment in Chinese adults?
Odds Ratio: 4.882 (95% CI 2.212–10.777)
Absolute Event Rate: 15.5% vs 2.6%
p-value: p=<0.0001
Elevated levels of Lp-PLA2 mass are independently associated with a higher prevalence of cognitive impairment, suggesting a potential link between vascular inflammation and cognitive decline.
Higher Lp-PLA2 levels were associated with cognitive impairment prevalence; leaves open causal role and need for prospective validation before clinical consideration.
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a unique circulating phospholipase with inflammatory and oxidative activities and the limited data regarding the relationship between Lp-PLA2 and cognitive impairment are conflicted. We conducted a cross-sectional study including 1,374 Chinese adults recruited from 2010 to 2011, aiming to evaluate the relationship between Lp-PLA2 levels and the prevalence of cognitive impairment in a Chinese community-based population. Participants underwent standardized evaluation. Serum Lp-PLA2 mass was measured by ELISA. Cognition status was evaluated via the Mini-Mental Status Exam (MMSE) and cognitive impairment was identified as MMSE <24. Multivariable logistic regression models were used to assess the associations of Lp-PLA2 mass with cognitive impairment. Lp-PLA2 mass was significantly associated with the prevalence of cognitive impairment after adjusting for other potential confounding factors (compared with the first quartile, adjusted ORs of the second, third, and fourth quartile were 2.058 (95% CI, 0.876-4.835), 2.834 (95% CI, 1.255-6.398), and 4.882 (95% CI, 2.212-10.777), p < 0.0001). In conclusion, elevated level of Lp-PLA2 mass was independently associated with the prevalence of cognitive impairment in Chinese adults.
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Jiang et al. (2016) conducted a cross-sectional in Cognitive impairment (n=1,374). Lipoprotein-associated phospholipase A2 (Lp-PLA2) mass vs. Lowest quartile of Lp-PLA2 mass was evaluated on Prevalence of cognitive impairment (MMSE < 24) (OR 4.882, 95% CI 2.212-10.777, p=<0.0001). Elevated levels of Lp-PLA2 mass in the highest quartile were independently associated with an increased prevalence of cognitive impairment compared to the lowest quartile (OR 4.882).
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