Practical Large Scale Synthesis of tert-Butyl (3R,5S)-6-Hydroxy-3,5-O-isopropylidene-3,5-dihydroxyhexanoate: Essential Building Block for HMG-CoA Reductase Inhibitors

All articles of this category Title compound 7 (96% ee, > 98% de) is synthesized enantioselectively in six steps (36% overall yield) from the commercial β -keto ester 8 on a multi-kg scale. asymmetric hydrogenation - syn - β , δ -dihydroxy carboxylate - HMG-CoA reductase inhibitor