What question did this study set out to answer?

To evaluate the impact of long-term dietary and physical activity interventions on DNA methylation of nonalcoholic fatty liver disease-related genes associated with intrahepatic fat.

May 3, 2021Liver International

Effects of lifestyle interventions on epigenetic signatures of liver fat: Central randomized controlled trial

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Authors

AMAnat Yaskolka MeirBen-Gurion University of the Negev MKMaria KellerHelmholtz Zentrum München LMLuise MüllerUniversity Hospital Leipzig

Discussion

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Implication

Randomized trial reveals diet and exercise alter DNA methylation of liver fat genes in adults, indicating lifestyle-induced epigenetic remodeling.

Key Points

To evaluate the impact of long-term dietary and physical activity interventions on DNA methylation of nonalcoholic fatty liver disease-related genes associated with intrahepatic fat.
Randomized 120 participants to an 18-month regimen of either a low-fat or Mediterranean-low carbohydrate diet, with or without physical activity.
Quantified intrahepatic fat percentage (IHF%) using magnetic resonance imaging and analyzed associations with CpG-specific DNA methylation levels across 41 candidate genes and related single-nucleotide polymorphisms.
Baseline IHF% (mean 10.7%, 59% with NAFLD) was inversely correlated with DNA methylation at specific CpGs within AC074286.1, CRACR2A, A2MP1, and FARP1 (P < .05 for all multivariate models).
Following 18 months, differential DNA methylation occurred between diet groups at cg14335324 in A2MP1 (P = .04, low-fat vs. Mediterranean-low carbohydrate).
Differential DNA methylation emerged between physical activity groups at CpG sites within AC074286.1, CRACR2A, and FARP1 (P < .05 for all comparisons).

Cite This Study

Meir et al. (2021) studied this question.

synapsesocial.com/papers/6a9aaed15e927c80f2869ade https://doi.org/10.1111/liv.14916

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May 3, 2021Liver International

Effects of lifestyle interventions on epigenetic signatures of liver fat: Central randomized controlled trial

View Full Paper

Ask AI

Bookmark

Authors

AMAnat Yaskolka MeirBen-Gurion University of the Negev MKMaria KellerHelmholtz Zentrum München LMLuise MüllerUniversity Hospital Leipzig

Discussion

Member takes

Implication

Randomized trial reveals diet and exercise alter DNA methylation of liver fat genes in adults, indicating lifestyle-induced epigenetic remodeling.

Key Points

To evaluate the impact of long-term dietary and physical activity interventions on DNA methylation of nonalcoholic fatty liver disease-related genes associated with intrahepatic fat.
Randomized 120 participants to an 18-month regimen of either a low-fat or Mediterranean-low carbohydrate diet, with or without physical activity.
Quantified intrahepatic fat percentage (IHF%) using magnetic resonance imaging and analyzed associations with CpG-specific DNA methylation levels across 41 candidate genes and related single-nucleotide polymorphisms.
Baseline IHF% (mean 10.7%, 59% with NAFLD) was inversely correlated with DNA methylation at specific CpGs within AC074286.1, CRACR2A, A2MP1, and FARP1 (P < .05 for all multivariate models).
Following 18 months, differential DNA methylation occurred between diet groups at cg14335324 in A2MP1 (P = .04, low-fat vs. Mediterranean-low carbohydrate).
Differential DNA methylation emerged between physical activity groups at CpG sites within AC074286.1, CRACR2A, and FARP1 (P < .05 for all comparisons).

Cite This Study

Meir et al. (2021) studied this question.

synapsesocial.com/papers/6a9aaed15e927c80f2869ade https://doi.org/10.1111/liv.14916

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