Key result
Intravenous potassium supplementation and anti-thyroid medications successfully resolved acute muscle paralysis and severe hypokalemia in a 35-year-old male with thyrotoxic periodic paralysis.
Why the study?
Thyrotoxic periodic paralysis is a rare complication of hyperthyroidism, and literature regarding its occurrence in Nepal is limited.
Case Report (n=1)
No
Thyrotoxic periodic paralysis is a rare but reversible cause of acute muscle weakness that requires prompt recognition and potassium supplementation along with restoration of euthyroid state.
May support potassium and antithyroid therapy in thyrotoxic periodic paralysis; hypothesis-generating and requires prospective validation.
Thyrotoxic periodic paralysis is rare complication of hyperthyroidism characterized by the sudden onset of hypokalemia and muscle paralysis. It is typically present in young Asian males. There are very few literatures regarding the occurrence of thyrotoxic hypokalemic periodic paralysis in Nepal. We reported a case of a 35-year-old male presented with the chief complaints of weakness of all four limbs of 1 day duration. He was diagnosed as a case of hyperthyroidism in the past, received treatment for 6 months and left medications on his own 6 months ago. Evaluation during admission revealed severe hypokalemia with serum potassium level 1.3mEq/l and high serum Triiodothyronine (>20.00µg/L) and low serum Thyroid Stimulating Hormone (<0.01µg/L). Potassium supplements resolved muscle weakness and the patient was restarted with anti-thyroid drugs. Hence, hypokalemic paralysis is a reversible cause of paralysis and high index of suspicion as well as timely interventions are required to prevent potential harm.
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Khadka et al. (2019) conducted a case report in Thyrotoxic Periodic Paralysis with Hypokalemia (n=1). Potassium supplementation and anti-thyroid drugs was evaluated on Resolution of muscle weakness and hypokalemia. Intravenous potassium supplementation and anti-thyroid medications successfully resolved acute muscle paralysis and severe hypokalemia in a 35-year-old male with thyrotoxic periodic paralysis.
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