Key result
Exosomes provide potential strategies for the diagnosis and treatment of cardiovascular disease based on existing preclinical studies.
Why the study?
Cardiovascular disease remains the leading cause of death globally, creating a need for valid risk-prediction biomarkers and novel therapeutic approaches.
This review highlights the emerging role of exosomes as potential diagnostic biomarkers and therapeutic tools in cardiovascular diseases, primarily based on preclinical evidence.
Answers are grounded in this paper and cite their sources.
Exosomes in CVD merit prospective human trials; leaves open diagnostic or therapeutic translation from preclinical data.
Cardiovascular disease (CVD) is the major cause of death globally; therefore, there is a need for the identification of a valid biomarker that accurately predicts the risk of developing CVD, and novel therapeutic approaches for its treatment. Exosomes are very small extracellular vesicles containing protein, lipid, transcription factors, messenger RNAs, noncoding RNA, and nucleic acid contents that are important players in intercellular communication, and that act via long-range signals or cell-to-cell contact. The discovery of exosomes provides potential strategies for the diagnosis and treatment of CVD. In the current review, we have explored the potential impact of exosomes on cardiovascular physiology, and their therapeutic potential in cardiovascular disorders with an emphasis on the existing preclinical studies.
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Ghafarian et al. (2018) conducted a review in Cardiovascular disease. Exosomes was evaluated. Exosomes provide potential strategies for the diagnosis and treatment of cardiovascular disease based on existing preclinical studies.
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