Why the study?
Cardiovascular diseases cause substantial mortality, making the study of molecular mechanisms such as exosomes and their potential as therapeutic targets important for developing new diagnostic and therapeutic strategies.
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Design
Literature review
Exosome research in CVD remains hypothesis-generating; leaves open diagnostic or therapeutic translation pending prospective validation.
According to World Health Organization, annually cardiovascular diseases cause 17,5 billion deaths in the developed world. This is the reason why the study of molecular mechanisms of these pathologies has a huge importance for the development of new diagnostic and therapeutic strategies. One of the strategies on this matter is the research of the small extracellular vesicles or exosomes and its role in pathogenesis of cardiovascular diseases. Exploring their transporting and signaling functions in the development of acute coronary syndrome, stable angina, heart valve diseases, hypertrophic cardiomyopathy, vascular atherosclerosis has a great importance. Exosomes are spherical vesicles of 30–100 nm, expressed by almost all human cells. Their cytoplasmic membrane has lipid bilayer structure with tetraspanins CD9, CD63, CD81 and CD82 as the markers. Exosomes act as effectors transferring microRNA, mRNA, cytokines and growth factors between varies cells. The aim of this review is to analyze the literature data of exosomal role in the development of main cardiologic syndrome’s and evaluation of existed literature on exosomes potential as therapeutic target.
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Schava et al. (2020) studied this question.
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