Key result
Exosomes and derived molecules act as key biomarkers and mediators of intercellular crosstalk in atherosclerosis.
Why the study?
The role of exosomes in cardiovascular diseases has received extensive attention, prompting an exploration of their mechanisms and biomarker potential in atherosclerosis.
This review highlights the emerging role of exosomes and their cargo as potential biomarkers and therapeutic targets in atherosclerosis.
Exosomes may advance atherosclerosis biomarker research; this review leaves open clinical translation pending prospective validation.
Atherosclerosis is the main reason for morbidity and death caused by cardiovascular disease which leads to approximately 20% of total death around the world. Exosomes secreted by the cells is a kind of extracellular vesicles with lipid bilayer structure, containing a variety of cell specific lipid, nucleic acid and protein, involved in intercellular communication, plays an important role in different physiological and pathological process. In recent years, with the deepening of research, the role of exosomes in cardiovascular diseases has received extensive attention. This review summarizes the roles of exosomes and exosome-derived from microRNAs, proteins and DNA as biomarkers in the development of atherosclerosis, and explores the mechanism of exosome-mediated intercellular crosstalk in atherosclerosis, providing potential roles for diagnosis and treatment.
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Wang et al. (2019) conducted a review in Atherosclerosis. Exosomes was evaluated. Exosomes and their derived microRNAs, proteins, and DNA play important roles as biomarkers and mediators of intercellular crosstalk in the development of atherosclerosis.
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