Key result
A previously healthy female teenager presenting with deep vein thrombosis was diagnosed with advanced epithelioid haemangioendothelioma, highlighting the association between cancer and thrombosis in children.
Why the study?
Venous thromboembolism is rare in children and does not usually prompt malignancy screening, with epithelioid haemangioendothelioma not previously reported presenting with deep vein thrombosis in a child.
Case Report (n=1)
Answers are grounded in this paper and cite their sources.
Clinicians should be mindful of the association between cancer and thrombosis, even in pediatric patients presenting with DVT.
Venous thromboembolism (VTE) is a rare event in children and does not usually trigger investigation for malignancy. We report the case of a previously healthy female teenager presenting with unilateral leg swelling. Colour-Doppler ultrasound confirmed deep vein thrombosis (DVT), and the thrombophilia workup was negative. Cross-sectional imaging identified multiple liver and lung lesions, diagnosed as epithelioid haemangioendothelioma (EHE) at biopsy. Lifelong anticoagulation was commenced; the patient was initially observed and then started on sirolimus at disease progression. We describe the first published case of EHE presenting with DVT in a child. Clinicians need to be mindful of the association between cancer and thrombosis, even in paediatric patients.
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Shields et al. (2024) conducted a case report in Epithelioid haemangioendothelioma presenting as deep vein thrombosis (n=1). Anticoagulation and sirolimus was evaluated. A previously healthy female teenager presenting with deep vein thrombosis was diagnosed with advanced epithelioid haemangioendothelioma, highlighting the association between cancer and thrombosis in children.
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