Key result
This article reviews preclinical evidence of anesthetic neurotoxicity and proposes a mixed epidemiologic study design to evaluate long-term neurodevelopmental outcomes in children exposed to anesthesia.
Why the study?
Does anesthesia exposure reduce neurocognitive function in children exposed before age 3 years?
Population
Children exposed to anesthesia during early childhood (before age 3 years)
Comparison
Anesthesia exposure vs Developmental age-matched siblings without…
Design
Review
Authors
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No clinical practice change indicated; leaves open whether early anesthesia impairs neurodevelopment in children, supporting proposed mixed epidemiologic studies.
Does anesthesia exposure reduce neurocognitive function in children exposed before age 3 years?
This paper highlights the urgent need for rigorous clinical studies to determine if early childhood exposure to anesthesia causes long-term neurodevelopmental deficits, proposing a specific mixed epidemiologic study design.
Sun et al. (2008) conducted a review in Anesthetic neurotoxicity. Anesthesia exposure vs. No anesthesia exposure was evaluated. This article reviews preclinical evidence of anesthetic neurotoxicity and proposes a mixed epidemiologic study design to evaluate long-term neurodevelopmental outcomes in children exposed to anesthesia.
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