Key result
Atorvastatin 10 mg daily significantly improved brachial artery flow-mediated vasodilation in postmenopausal hypercholesterolemic women compared to diet (11.7% vs 3.3% at 8 weeks).
Why the study?
Does atorvastatin 10 mg daily improve endothelial function in postmenopausal hypercholesterolemic women?
Population
30 postmenopausal hypercholesterolemic women, mean age 58 +/- 6 years.
Comparison
Atorvastatin 10 mg daily for 8 weeks. vs American Heart Association step 1 diet for 8…
Design
Cohort
Follow-up
8 weeks
Authors
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May support early endothelial benefits of low-dose atorvastatin; hypothesis-generating and requires randomized confirmation.
Does atorvastatin 10 mg daily improve endothelial function in postmenopausal hypercholesterolemic women?
Absolute Event Rate: 11.7% vs 3.3%
p-value: p=<0.05
Atorvastatin 10 mg daily significantly improves endothelial reactivity in postmenopausal hypercholesterolemic women as early as 2 weeks into therapy.
Marchesi et al. (2000) studied Hypercholesterolemia (n=30). Atorvastatin vs. American Heart Association step 1 diet was evaluated on Brachial artery flow-mediated vasodilation (FMV) at 8 weeks (p=<0.05). Atorvastatin 10 mg daily significantly improved brachial artery flow-mediated vasodilation in postmenopausal hypercholesterolemic women compared to diet (11.7% vs 3.3% at 8 weeks).
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