Key result
Enteric viral RNA was found in 0% of children with inflammatory bowel disease compared to 17.6% of children without the disease, suggesting enteral viruses play a minor role in IBD.
Why the study?
Does the presence of enteric viral pathogens differ between children with and without inflammatory bowel disease?
Cross-Sectional (n=50)
Does the presence of enteric viral pathogens differ between children with and without inflammatory bowel disease?
Absolute Event Rate: 0% vs 17.6%
Enteral viruses appear to play only a minor role in exacerbations of inflammatory bowel disease in children.
Enteric viruses unlikely to drive pediatric IBD exacerbations; hypothesis-generating and requires prospective confirmation before clinical adoption.
The causes of exacerbations of inflammatory bowel disease (IBD) are unknown. The presence of RNA of an enterovirus, norovirus GI, norovirus GII, rotavirus, astrovirus, and sapovirus was sought in stool samples of 50 children (median age 12.9 years) undergoing gastrointestinal endoscopies for IBD or its exclusion (Crohn's disease n = 18, ulcerative colitis n = 13, indeterminate colitis n = 2, non-IBD n = 17). Viral RNA was found in three fecal samples (norovirus GII n = 2, sapovirus n = 1), all in children without IBD. Therefore, enteral viruses may play only a minor role in IBD.
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Kolho et al. (2011) conducted a cross-sectional in Inflammatory bowel disease (n=50). Inflammatory bowel disease vs. Non-inflammatory bowel disease was evaluated on Presence of enteric viral RNA in stool samples. Enteric viral RNA was found in 0% of children with inflammatory bowel disease compared to 17.6% of children without the disease, suggesting enteral viruses play a minor role in IBD.
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