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February 6, 2013Epidemiology and InfectionOpen Access

Seasonal pattern of hepatitis E virus prevalence in swine in two different geographical areas of China

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Key result

The prevalence of HEV RNA in swine exhibited distinct seasonal patterns differing by geographical area in China, with a major peak during March-April in the east and September-October in the southwest.

Population

4200 swine bile specimens collected from eastern and southwestern China

Design

Cross-sectional

Follow-up

2008 to 2011 (collection period)

Authors

YLYihan LuHQHan‐Zhu QianAHAnqun Hu

Discussion

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Overview

Swine HEV surveillance may need regional seasonal timing; cross-sectional data leaves open human transmission implications.

Study Design

Type

Cross-Sectional (n=4,200)

Multicenter

Yes

Structured PICO

P
Population
4,200 swine bile specimens from 4-6 month old pigs in two Chinese cities were tested for HEV RNA to determine seasonal prevalence patterns.
O
Outcome
Prevalence of hepatitis E virus (HEV) RNA and seasonal patternssurrogate

Main Result

Absolute Event Rate: 3.83% vs 2.61%

The distribution of HEV subtypes in swine in China is associated with distinct seasonal patterns that vary by geographical area.

Limitations

  • Specimens were collected only from slaughterhouses in two cities, which may not represent the entire swine population.
  • An unexpected peak of subtype 4a in Nanning in 2011 confounded the seasonal pattern.
  • Lack of concurrent human epidemiological data in the same areas to correlate with swine findings.

Cite This Study

Lu et al. (2013) conducted a cross-sectional in Hepatitis E virus (HEV) infection (n=4,200). Geographical area and season was evaluated on HEV RNA prevalence. The prevalence of HEV RNA in swine exhibited distinct seasonal patterns differing by geographical area in China, with a major peak during March-April in the east and September-October in the southwest.

synapsesocial.com/papers/6a9abfca3be7bd97fa0e5ab3https://doi.org/10.1017/s0950268813000113
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of real‐time fluorescent RT‐PCR and conventional RT‐PCR for the detection of hepatitis E virus genotypes prevalent in China2007 · 49 citations
  2. 2Molecular tracing of Japan-indigenous hepatitis E viruses2006 · 46 citations
  3. 3Type‐IV Indian swine HEV infects rhesus monkeys2006 · 73 citations