Analytical study demonstrates sensitive high-performance liquid chromatographic quantification of ciprofloxacin in patient plasma samples, highlighting a reliable tool for therapeutic monitoring.
This paper describes an accurate, specific and sensitive high-performance liquid chromatographic (HPLC) method for the determination of ciprofloxacin in small samples (0.5 ml). The samples, after pretreatment by solvent extraction, were eluted on a reversed-phase column and detected by an ultraviolet detector. The results obtained on patient samples are presented.
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Mehta et al. (1992) studied this question.
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