Key result
Lower elastic modulus of polymeric heart valves increased the effective orifice area, and positioning the valve closer to the sinuses achieved greater effective orifice area and lower leaflet stresses.
Why the study?
Computational modeling and numerical simulation of heart valve dynamics incorporating fluid dynamics and valve structural replications has been challenging.
Does valve elasticity and position affect hemodynamics and EOA in a computational model of polymeric heart valves?
Does valve elasticity and position affect hemodynamics and EOA in a computational model of polymeric heart valves?
Computational modeling suggests that lower elastic modulus and positioning closer to the sinuses optimize the effective orifice area and reduce leaflet stress in polymeric transcatheter aortic valves.
May inform polymeric valve design; hypothesis-generating from Level 5 modeling and should not yet change practice.
Computational modeling and numerical simulation of heart valve dynamics incorporating both fluid dynamics and valve structural replications has been challenging. In this study, we developed a double-coupled fluid-structure interaction (FSI) model using arbitrary lagrangian eulerian(ALE) and steered adaptive mesh(SAM). So we were looking to simulate transcatheter aortic valve (TAV) hemodynamic performance throughout entire cardiac cycles [1]. To reach this object, semi-real geometry of aorta and aortic polymeric valves has been created. At model inlet, left ventricular pressure and at the model outlet the elastic porous tube have been considered. Nonlinear finite element way and Sparse solver was utilized to couple fluid and solid equation. Consequently, extensive and comparative simulation were performed to investigate the impact of valve elasticity and valve positions on hemodynamics and solid parameters. Effective Orifice Area(EOA) also has been calculated [1]. The simulation results indicated that the lower of the elastic modulus cause to increase the EOA. Furthermore, the result of valve position showed, whenever the valve is closer to sinuses, a greater EOA and lower stresses impose on the leaflet are achievable.
No takes yet. Share an insight, caveat, or question.
Farokhi et al. (2021) studied Transcatheter aortic valve hemodynamics. Polymeric heart valves (varying elasticity and position) was evaluated on Effective Orifice Area (EOA) and leaflet stresses. Lower elastic modulus of polymeric heart valves increased the effective orifice area, and positioning the valve closer to the sinuses achieved greater effective orifice area and lower leaflet stresses.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: