Key result
Total serum cholesterol levels measured within 24 hours of out-of-hospital cardiac arrest were associated with neurologic outcomes upon discharge (OR 2.00; 95% CI 1.01-3.96; p=0.045).
Why the study?
The association between total serum cholesterol levels and outcomes upon discharge in patients hospitalized after out-of-hospital cardiac arrest was unclear.
Are initial serum cholesterol levels associated with neurological outcomes and survival to discharge in patients hospitalized after out-of-hospital cardiac arrest?
Observational (n=689)
Yes
Are initial serum cholesterol levels associated with neurological outcomes and survival to discharge in patients hospitalized after out-of-hospital cardiac arrest?
Odds Ratio: 2 (95% CI 1.01–3.96)
p-value: p=0.045
Low initial total serum cholesterol levels measured within 24 hours of admission are associated with poor neurologic outcomes and increased in-hospital mortality in patients after out-of-hospital cardiac arrest.
Does not support altering lipid management post-OHCA; leaves open whether cholesterol is causal or a modifiable target.
Purpose: This study aimed to investigate the association between total serum cholesterol levels and outcomes upon discharge in patients after out-of-hospital cardiac arrest (OHCA). Methods: We performed a retrospective observational study using the Korean Cardiac Arrest Resuscitation Consortium (KoCARC) registry. Patients after OHCA whose total serum cholesterol levels were measured within 24 h after arriving at the emergency department were included in the analysis. The association between total serum cholesterol level and neurological outcomes upon discharge and survival to discharge was estimated. Results: Of the 12,321 patients after OHCA enrolled in the registry from October 2015 to June 2020, 689 patients were included. The poor neurologic outcome upon discharge group had a statistically significant lower total serum cholesterol level compared to the good neurologic outcome group (127.5 ± 45.1 mg/dL vs. 155.1 ± 48.9 mg/dL, p < 0.001). As a result of multivariate logistic regression analysis, the odds ratio for the neurologic outcome of total serum cholesterol levels was 2.00 (95% confidence interval [CI] 1.01–3.96, p = 0.045). The odds ratio for in-hospital death was 1.72 (95% CI 1.15–2.57, p = 0.009). Conclusions: Low total serum cholesterol levels could be associated with poor neurologic outcomes upon discharge and in-hospital death of patients hospitalized after OHCA.
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Lee et al. (2022) conducted an observational in out-of-hospital cardiac arrest (OHCA) (n=689). Total serum cholesterol levels was evaluated on neurologic outcomes upon discharge (OR 2.00, 95% CI 1.01-3.96, p=0.045). Total serum cholesterol levels measured within 24 hours of out-of-hospital cardiac arrest were associated with neurologic outcomes upon discharge (OR 2.00; 95% CI 1.01-3.96; p=0.045).
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