Key result
Increasing CO2 and HCO3- concentrations at constant pH increased force development during hypoxia in carp and trout myocardial strips, and improved force recovery upon reoxygenation in trout strips.
Population
Isometrically mounted and electrically paced myocardial ventricular strips of carp and rainbow trout
Comparison
Increased concentrations of CO2 and HCO3- at… vs Standard conditions
Design
Preclinical
Authors
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No clinical implications in humans; leaves open whether elevated CO2/HCO3- protects mammalian myocardium during hypoxia.
Increased CO2 and HCO3- concentrations at constant pH exert a protective effect on myocardial force development during hypoxia and reoxygenation in fish models.
H. Gesser (1977) studied this question. Increased concentrations of CO2 and HCO3- vs. Baseline/lower concentrations was evaluated on Force development during hypoxia and force recovery upon reoxygenation. Increasing CO2 and HCO3- concentrations at constant pH increased force development during hypoxia in carp and trout myocardial strips, and improved force recovery upon reoxygenation in trout strips.
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