Key result
In healthy adults, pulse wave velocity and augmentation index demonstrated excellent same-day repeatability (ICC 0.96 and 0.90, respectively) and good week-to-week reproducibility.
Why the study?
Arterial stiffness is an important cardiovascular risk factor, and the study aimed to evaluate the repeatability and reproducibility of pulse wave velocity and augmentation index in healthy individuals.
Are central pulse wave velocity and augmentation index repeatable and reproducible measures of arterial stiffness in healthy adults?
Observational (n=40)
No
Are central pulse wave velocity and augmentation index repeatable and reproducible measures of arterial stiffness in healthy adults?
PWV and AIx measured by the SphygmoCor Xcel device demonstrate excellent repeatability and good reproducibility in healthy adults, supporting their potential use in routine clinical practice for cardiovascular risk stratification.
Purpose: Arterial stiffness is an important cardiovascular risk factor. Pulse wave velocity (PWV) and augmentation index (Alx) are established indicators of arterial stiffness. The present study aimed to evaluate the repeatability and reproducibility of PWV and Alx in healthy individuals. Methods: Forty healthy participants (age 33±11 years, 17 females) underwent resting supine PWV and Alx assessments. Measurements were made in triplicate and repeated one week apart. Alx was measured by brachial occlusion and PWV was measured from the carotid artery to the femoral artery by the tonometer - oscillometric method. Repeatability and reproducibility were assessed using intra-class correlation coefficient (ICC). Inter-operator reproducibility was performed on ten participants. Results: The average values for week-to-week visits for PWV and Alx were 6.20±0.91 vs 6.13±0.91 ms-1 and 14.0±11.8 vs 16.3±12.2 %. For same-day measurements, both PWV and Alx showed excellent repeatability (PWV: ICC=0.96, 95% CI 0.92-0.98, p<0.01; and Alx: ICC=0.90 95% CI 0.84-0.94, p<0.01) and inter-operator reproducibility (PWV: ICC=0.98, 95% CI 0.93-1.00, p<0.01; and Alx: ICC=0.93 95% CI 0.69-0.98, p<0.01). Measurements were repeated one week apart and showed good reproducibility (PWV: ICC=0.77, 95% CI 0.61-0.87, p=<0.01; and Alx: ICC=0.73 95% CI 0.73-0.86, p<0.01). Conclusion: PWV and Alx demonstrate excellent repeatability and good reproducibility. Considering these variables are non-invasive and easy-to-measure, arterial stiffness may have a role in routine clinical practice to facilitate risk stratification in cardiovascular diseases.
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Russell et al. (2023) conducted an observational in Healthy individuals (n=40). Pulse wave velocity and augmentation index measurement was evaluated on Same-day repeatability of pulse wave velocity (PWV) (ICC 0.96, 95% CI 0.92-0.98, p=<0.01). In healthy adults, pulse wave velocity and augmentation index demonstrated excellent same-day repeatability (ICC 0.96 and 0.90, respectively) and good week-to-week reproducibility.
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