Synthesis and Application of Graphene–Sodium Polyacrylate–Pd Nanocomposite in Amperometric Determination of Ciprofloxacin

Graphene–sodium polyacrylate–Pd (GN–PAAS–Pd) nanocomposite was synthesized and applied to the amperometric determination of ciprofloxacin (CIP). The electrochemical behaviour of CIP on the nanocomposite was investigated and a chronoamperometry method was developed for the determination of CIP. The results showed that the peak current increased with the CIP concentration in the range 0.18–10.8 µM with a calibration equation of Ipa (µA) = 0.867CCIP + 0.6521(µM) and in the range 10.8–180 µM with a calibration equation of Ipa (µA) = 0.1593CCIP + 8.2671(µM). The detection limit was estimated to be 0.045 µM (S/N = 3). The modified electrode has been applied to the determination of CIP in samples.