Key result
A 3D computational model of blood flow demonstrated an evident hysteresis loop in the pressure-diameter relationship of the normal viscoelastic aorta and altered flow patterns in abnormal morphology.
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A 3D computational model using the immersed boundary method successfully simulates altered hemodynamics in normal, aneurysmal, and stenotic aortas, potentially aiding early noninvasive detection of arterial diseases.
Arterial diseases such as aneurysm and stenosis may result from the mechanical and/or morphological change of an arterial wall structure and correspondingly altered hemodynamics. The development of a 3D computational model of blood flow can be useful to study the hemodynamics in major blood vessels and may provide an insight into the noninvasive technique to detect arterial diseases in early stage. In this paper, we present a three-dimensional model of blood flow in the aorta, which is based on the immersed boundary method to describe the interaction of blood flow with the aortic wall. Our simulation results show that the hysteresis loop is evident in the pressure-diameter relationship of the normal aorta when the arterial wall is considered to be viscoelastic. In addition, it is shown that flow patterns and pressure distributions are altered in response to the change of aortic morphology.
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Kim et al. (2016) studied Arterial diseases (aneurysm and stenosis). 3D computational model of blood flow using immersed boundary method was evaluated on Hemodynamics, flow patterns, and pressure distributions. A 3D computational model of blood flow demonstrated an evident hysteresis loop in the pressure-diameter relationship of the normal viscoelastic aorta and altered flow patterns in abnormal morphology.
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