Comparative neutralisation profile of SARS-CoV-2 omicron subvariants BA.2.75 and BA.5

Following the emergence of the SARS-CoV-2 omicron variant in November, 2021, several omicron subvariants have been circulating globally, including BA.1, BA.2, BA.2.12.1, BA.2.75, BA.4, and BA.5. Unique spike mutations in omicron subvariants have resulted in the substantial ability of the virus to escape neutralising antibodies.1–4 Within a few months after the emergence of BA.5, the most recent omicron subvariant, BA.2.75, was detected in June, 2022, in India and Japan (appendix p 4), carrying nine additional mutations in the spike protein that were not present in BA.2 (appendix p 5).