What question did this study set out to answer?

To evaluate the clinical and microbiological efficacy of trimethoprim-sulphadiazine compared with placebo in men with nongonococcal urethritis and their female sexual partners.

April 1, 1980Sexually Transmitted InfectionsOpen Access

Treatment of nongonococcal urethritis with trimethoprim-sulphadiazine and with placebo. A double-blind partner-controlled study.

View Full Paper

Ask AI

Bookmark

Authors

JPJorma PaavonenUniversity of Helsinki MKM KousaUniversity of Helsinki PSPekka SaikkuUniversity of Oulu

Discussion

Member takes

Implication

Double-blind trial demonstrates trimethoprim-sulphadiazine clears Chlamydia trachomatis in nongonococcal urethritis couples, indicating placebo risks severe complications.

Key Points

To evaluate the clinical and microbiological efficacy of trimethoprim-sulphadiazine compared with placebo in men with nongonococcal urethritis and their female sexual partners.
Double-blind, partner-controlled trial involving 75 men with nongonococcal urethritis and their female sexual partners.
Couples were assigned to receive either active trimethoprim-sulphadiazine (34 pairs) or placebo, with microbiological follow-up conducted at four weeks.
In the active treatment arm, Chlamydia trachomatis was eradicated in 18 of 19 men and 14 of 15 women, leaving 1 positive culture per sex post-treatment.
In the placebo arm, 16 of 21 men and 15 of 15 women remained culture-positive at four weeks, and 5 chlamydia-positive patients developed severe complications (epididymitis, arthritis, or salpingitis), prompting early trial termination.

Cite This Study

Paavonen et al. (1980) studied this question.

synapsesocial.com/papers/6a9ad2e1d7a9d2ca6590b679 https://doi.org/10.1136/sti.56.2.101

View Full Paper

Ask AI

Bookmark

Implication

Double-blind trial demonstrates trimethoprim-sulphadiazine clears Chlamydia trachomatis in nongonococcal urethritis couples, indicating placebo risks severe complications.

Treatment of nongonococcal urethritis with trimethoprim-sulphadiazine and with placebo. A double-blind partner-controlled study.

Discussion

Member takes

Implication

Key Points

Cite This Study

Treatment of nongonococcal urethritis with trimethoprim-sulphadiazine and with placebo. A double-blind partner-controlled study.

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider