Key result
Oral administration of 500 mg acetazolamide decreased mean ocular pulse amplitude from 2.76 mmHg to 2.14 mmHg and reduced intraocular pressure by 2.98 mmHg at 2 hours.
Why the study?
Does oral acetazolamide reduce ocular pulse amplitude and intraocular pressure in patients with hypertensive primary open-angle glaucoma and healthy controls?
Does oral acetazolamide reduce ocular pulse amplitude and intraocular pressure in patients with hypertensive primary open-angle glaucoma and healthy controls?
Oral acetazolamide significantly decreases ocular pulse amplitude and intraocular pressure, which must be considered when measuring OPA with dynamic contour tonometry.
Answers are grounded in this paper and cite their sources.
Acetazolamide was associated with reduced OPA and IOP; leaves open effects on dynamic contour tonometry interpretation in glaucoma.
PURPOSE: To investigate the effect of systemic acetazolamide on ocular pulse amplitude (OPA) and on intraocular pressure (IOP). METHODS: We determined OPA, IOP, mean arterial blood pressure and heart rate (HR) in 17 patients suffering from hypertensive primary open-angle glaucoma (htPOAG) and 22 healthy controls. Measurements were taken before and 2 h after oral intake of 500 mg of acetazolamide. RESULTS: Mean OPA decreased 20.24% (SEM 2.95%) from 2.76 mmHg (SEM 0.16 mmHg) to 2.14 mmHg (SEM 0.13 mmHg) 2 h after oral administration of 500-mg acetazolamide. IOP dropped by 2.98 mmHg (SEM 0.28 mmHg), corresponding to a 17.19% (SEM 1.56%) reduction. The decrease in IOP correlated with the decrease of OPA (r(2) = 0.4, P < 0.0001). CONCLUSIONS: Ocular pulse amplitude measurements are influenced by oral administration of acetazolamide. There was a decrease in the pulsatile component of choroidal blood flow and in IOP in both htPOAG and healthy controls. This needs to be taken into account for measurement of OPA with dynamic contour tonometry.
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Zinkernagel et al. (2009) studied hypertensive primary open-angle glaucoma (n=39). Acetazolamide vs. Baseline was evaluated on Ocular pulse amplitude (OPA) (20.24% decrease). Oral administration of 500 mg acetazolamide decreased mean ocular pulse amplitude from 2.76 mmHg to 2.14 mmHg and reduced intraocular pressure by 2.98 mmHg at 2 hours.
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