Why the study?
Does an i.v. bolus of acetazolamide increase cerebral blood flow in healthy humans?
Population
Unanesthetized healthy human beings
Comparison
Acetazolamide 500 mg as an i.v. bolus vs Baseline (before injection)
Design
Other
Follow-up
Acute
Authors
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Acetazolamide may increase CBF independently of PCO2 or pH in healthy subjects; leaves open translation to cerebrovascular disease.
Does an i.v. bolus of acetazolamide increase cerebral blood flow in healthy humans?
Acetazolamide causes rapid cerebral vasodilation independent of its systemic carbonic anhydrase inhibitory effects on PCO2 and pH.
Hauge et al. (1983) studied this question.