Why the study?
Does transcranial Doppler sonography with acetazolamide stimulation accurately assess cerebrovascular reserve capacity compared to Xenon-133 SPECT in patients with obstructive carotid artery disease?
Population
33 normal persons and 21 patients with obstructive carotid artery disease and symptoms of cerebral ischemia
Comparison
Transcranial Doppler sonography with 1 g… vs Xenon-133 dynamic single-photon emission…
Design
Cross-sectional
Authors
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Supports TCD acetazolamide testing as feasible SPECT alternative; hypothesis-generating, needs prospective validation before practice change.
Does transcranial Doppler sonography with acetazolamide stimulation accurately assess cerebrovascular reserve capacity compared to Xenon-133 SPECT in patients with obstructive carotid artery disease?
Transcranial Doppler sonography with acetazolamide stimulation offers a simple and reliable method for assessing cerebrovascular reserve capacity, correlating well with Xenon-133 SPECT.
Piepgras et al. (1990) studied this question.
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