Why the study?
Does transcranial Doppler assessment before and after acetazolamide infusion identify impaired cerebral perfusion reserve in patients with carotid occlusive disease?
Population
20 patients without cerebral infarction, including 7 with normal carotid arteries, 7 with unilateral…
Comparison
Intravenous infusion of 1 gram of acetazolamide vs Baseline measurements and comparison across the…
Design
Cross-sectional
Follow-up
10 minutes
Authors
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May support risk stratification in carotid occlusive disease; leaves open prospective validation before clinical use.
Does transcranial Doppler assessment before and after acetazolamide infusion identify impaired cerebral perfusion reserve in patients with carotid occlusive disease?
The TCD-acetazolamide test reveals impaired cerebral perfusion reserve in patients with carotid occlusive disease, particularly those with TIAs, potentially identifying a subgroup at higher risk for stroke.
Chimowitz et al. (1993) studied this question.
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