July 1, 1997Journal of Neuroimaging
Vasodilatory Responses and Magnetic Resonance Angiography
Why the study?
Does acetazolamide challenge with phase-contrast magnetic resonance angiography differentiate the degree of hemodynamic compromise in patients with varying carotid artery disease?
Population
28 patients subdivided into four groups: Group I, Group II, Group III, and Group IV.
Comparison
Acetazolamide administration evaluated using… vs Baseline values and comparison between patient…
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Phase-contrast MRA with acetazolamide may differentiate hemodynamic compromise severity in carotid disease; leaves open whether it should guide management.
Structured PICO
Does acetazolamide challenge with phase-contrast magnetic resonance angiography differentiate the degree of hemodynamic compromise in patients with varying carotid artery disease?
P
Population
28 patients subdivided into four groups: Group I (nonocclusive, asymptomatic, n=7), Group II (unilateral carotid transient ischemic attacks, embolic, varying stenoses, n=11), Group III (unilateral carotid transient ischemic attacks, hemodynamic, varying stenoses, n=5), and Group IV (unilateral carotid occlusion, asymptomatic, n=5).
I
Intervention
Acetazolamide administration evaluated using phase-contrast magnetic resonance angiography
C
Comparator
Baseline values and comparison between patient groups (ischemic vs nonischemic sides)
O
Outcome
Responses of extracranial (internal carotid arteries) and intracranial (middle cerebral/angular, basilar arteries) intravascular arterial volume flow ratessurrogate
Phase-contrast magnetic resonance angiography with acetazolamide challenge can assist in determining the degree of hemodynamic compromise in specific vascular territories.
Cite This Study
Levine et al. (1997) studied this question.