Key result
Serum resistin levels (SMD 0.687; 95% CI 0.070-1.304; p=0.029) and HOMA-IR scores were significantly elevated in patients with non-alcoholic fatty liver disease compared to controls.
Why the study?
Studies have focused on adipose tissue influence in NAFLD, but the nature and magnitude of the association of serum resistin and HOMA-IR score with NAFLD pathophysiology required quantification.
Are serum resistin levels and HOMA-IR scores elevated in patients with NAFLD compared to controls?
Meta-Analysis (n=1,336)
Are serum resistin levels and HOMA-IR scores elevated in patients with NAFLD compared to controls?
Standardized Mean Difference: 0.687 (95% CI 0.07–1.304)
p-value: p=0.029
Serum resistin levels and HOMA-IR scores are significantly elevated in patients with NAFLD, suggesting an association with disease pathogenesis.
Supports resistin and HOMA-IR as NAFLD markers; leaves open causal roles and therapeutic implications.
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) comorbidity with adipose tissue dysfunction is not new and studies have focused on how adipose tissue influences NAFLD pathophysiology. OBJECTIVE: Quantification of nature and magnitude of the association between serum resistin and also insulin resistance, by calculating pooled Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) score, with NAFLD pathophysiology was the objective of the current study. METHODS: Using systematic review and meta-analysis and standardized mean difference (SMD) as the effect size, the levels of resistin and HOMA-IR scores have been investigated in NAFLD subjects in comparison with controls in the case-control studies using random-effects models. RESULTS: This meta-analysis retrieved a total number of 665 and 522 cases and 671 and 555 control subjects until May 2020 for serum levels of resistin and HOMA-IR score until May 2020. The final analyses demonstrated that pooled SMD of resistin and HOMA-IR score was 0.687 (95% confidence interval, 0.070–1.304) and 1.368 (95% confidence interval, 1.080–1.655); respectively. Moreover, the p-value for the test of significance for each pooled SMD was examined by the z-test and calculated as 0.029 and 0.000 for resistin and HOMA-IR score (clearly considered as statistically significant). CONCLUSION: Based on the findings, the HOMA-IR score and the serum levels of resistin in NAFLD subjects are associated with disease pathogenesis.
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Mirzaei et al. (2021) conducted a meta-analysis in Non-alcoholic fatty liver disease (NAFLD) (n=1,336). Serum resistin and HOMA-IR vs. Controls was evaluated on Serum levels of resistin (SMD 0.687, 95% CI 0.070-1.304, p=0.029). Serum resistin levels (SMD 0.687; 95% CI 0.070-1.304; p=0.029) and HOMA-IR scores were significantly elevated in patients with non-alcoholic fatty liver disease compared to controls.
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