Key result
Induced hypoglycemia caused significant QT interval prolongation when measured by the slope-intersect method for QTcB (42 ms; P<0.001) and QTcF (35 ms; P<0.001), though not reaching pathologic values.
Why the study?
Does the method of QT measurement and heart rate correction influence the assessment of QT prolongation during hypoglycemia in adults with type 1 diabetes?
RCT (n=10)
Does the method of QT measurement and heart rate correction influence the assessment of QT prolongation during hypoglycemia in adults with type 1 diabetes?
Mean Difference: 42
p-value: p=< .001
The methodology used to measure and correct the QT interval significantly impacts the detection and magnitude of QT prolongation during hypoglycemia.
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QT measurement method affects detected hypoglycemia-induced QTc prolongation; leaves open arrhythmic relevance in type 1 diabetes.
Christensen et al. (2010) conducted an RCT in Type 1 diabetes (n=10). Induced hypoglycemia via intravenous injection of two insulin types vs. Baseline/euglycemia was evaluated on QT interval prolongation during hypoglycemia (42 ms (SI QTcB), p=< .001). Induced hypoglycemia caused significant QT interval prolongation when measured by the slope-intersect method for QTcB (42 ms; P<0.001) and QTcF (35 ms; P<0.001), though not reaching pathologic values.
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