Key result
Blood donation did not significantly alter systolic time intervals or heart rate, but changes in the PEP/LVET-ratio correlated with the rate of blood withdrawal adjusted for bodyweight (r=0.76).
Why the study?
Does the usual blood-taking procedure influence systolic time intervals and heart rate in blood donors?
Observational (n=11)
Does the usual blood-taking procedure influence systolic time intervals and heart rate in blood donors?
To avoid a negative influence on left ventricular function, the blood-taking time in minutes should not be shorter than the quotient of donated volume of blood and bodyweight.
Answers are grounded in this paper and cite their sources.
Blood donation rate per body weight was associated with PEP/LVET changes; hypothesis-generating for rate effects on LV function in donors.
The systolic time intervals and heart rate were studied in 11 blood-donors aged between 20 and 48 years by a non-invasive technique before and after the usual blood-taking procedure. No statistically significant difference was found between values determined before and after the procedure. A significant correlation (r = 0.76) was demonstrated between percent changes of pre-ejection period/left ventricular ejection time (PEP/LVET)-ratio and withdrawn volume of blood (450 ml) X time (min)-1 X bodyweight (kg)-1. No correlation was found between percent changes of PEP/LVET-ratio and withdrawn volume of blood X time-1, nor between percent changes of PEP/LVET-ratio and withdrawn volume of blood X percentage of circulatory volume removed-1. It is suggested that the blood-taking time (in minutes) should not be shorter than the quotient: donated volume of blood (ml) X bodyweight (kg)-1 if a negative influence of withdrawal procedure on left ventricular function is to be avoided. Mechanisms contributing to circulatory stability during reduction of blood volume are briefly discussed.
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Ibler et al. (1984) conducted an observational in Blood donors (n=11). Blood-taking procedure vs. Before procedure was evaluated on Systolic time intervals and heart rate (r = 0.76). Blood donation did not significantly alter systolic time intervals or heart rate, but changes in the PEP/LVET-ratio correlated with the rate of blood withdrawal adjusted for bodyweight (r=0.76).
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