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September 1, 1998Clinical Science

Human cardiovascular variability, baroreflex and hormonal adaptations to a blood donation

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Why the study?

Does whole-blood donation alter cardiovascular variability, baroreflex sensitivity, and hormonal levels in blood donors?

Population

8 blood donors

Comparison

Whole-blood donation of 480+/-10 ml vs Baseline (20 min before donation)

Design

Other

Follow-up

5 min after donation

Authors

JFJacques‐Olivier FortratONOlivier NasrMDMonique Duvareille

Discussion

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Overview

May prompt closer post-donation BP monitoring in at-risk donors; leaves open effects on variability and baroreflex in larger cohorts.

Structured PICO

Does whole-blood donation alter cardiovascular variability, baroreflex sensitivity, and hormonal levels in blood donors?

P
Population
8 blood donors
I
Intervention
Whole-blood donation of 480+/-10 ml (about 7 ml/kg of blood volume, over 4 min)
C
Comparator
Baseline (20 min before donation)
O
Outcome
Changes in cardiovascular variability, baroreflex sensitivity, and blood volume regulating hormones (plasma catecholamines, vasopressin, atrial natriuretic peptide, endothelin, active renin, osmolality, Na+, K+, haemoglobin, and haematocrit)surrogate

Blood donation induces sympathetic activation and increases systolic blood pressure without altering heart rate or baroreflex sensitivity, likely due to counterbalancing by high supine vagal tone.

Cite This Study

Fortrat et al. (1998) studied this question.

synapsesocial.com/papers/6a89cb58af65c378f7fd49f1https://doi.org/10.1042/cs0950269
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