Key result
Regular blood donation linked to ~2% lower 24-hour SBP in untreated hypertension unless anemia develops.
Why the study?
The study was conducted to evaluate the impact of whole blood donation on blood pressure in hypertensive donors.
Does whole blood donation impact blood pressure in frequent donors with untreated stage 1 hypertension?
Cohort (n=100)
No
Does whole blood donation impact blood pressure in frequent donors with untreated stage 1 hypertension?
p-value: p=<0.05
Whole blood donation may lower blood pressure in untreated stage 1 hypertensive donors, provided it does not lead to anemia, which paradoxically increases blood pressure.
Caution against using donation for BP control in stage 1 hypertension; leaves open whether anemia avoidance enables benefit in trials.
At present, blood donation and donors’ health are the imperatives of the healthcare system. The aim of the paper is to study the impact of blood donation on blood pressure in hypertensive donors. Materials and Methods. During 12 months, the authors examined and followed-up 100 frequent whole blood donors, aged 40.3±7.5, with stage 1 hypertension. The donors did not receive any drug treatment for hypertension. The authors also monitored erythrocyte and hemoglobin levels, and 24-hour blood pressure. Statistica 10 software was used for statistical data analysis. Results. The study revealed that the dynamics of blood pressure depended on anemia, which could develop as a result of blood donations. Thus, one year after the 1st blood donation, we observed an increase in 24-hour mean SBP by 4.0 % (p<0.05), 24-hour mean DBP by 3.9 % (p<0.05), daytime SBP variability by 33 % (p<0.05), and daytime DBP variability by 28.8 % (p<0.05) in 17 blood donors with hypertension in case of anemia progression. Pathological BP rhythms also increased. We noted a statistically significant (p<0.05) decrease in SBP and DBP, as well as SBP and DBP variability in 83 donors with hypertension who did not develop anemia in 12 months. Conclusion. Whole blood donors with stage 1 hypertension, who do not undergo antihypertensive therapy, demonstrate positive blood pressure dynamics, whereas those who develop anemia as a result of blood donations show negative blood pressure dynamics.
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Разин et al. (2023) conducted a cohort in Stage 1 hypertension (n=100). Whole blood donation vs. Baseline was evaluated on Change in 24-hour mean systolic and diastolic blood pressure from baseline to 12 months (p=<0.05). In untreated stage 1 hypertensive patients, regular whole blood donation decreased 24-hour mean systolic blood pressure by 2.2% in those who did not develop anemia, but increased it by 4.3% in those who developed anemia.
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