Key result
Donation of 900 mL of blood in healthy semi-recumbent men did not significantly affect central blood volume measured by thoracic electrical impedance and plasma proANP compared to sham donation.
Why the study?
Withdrawal of 900 mL of blood decreases cardiac output, but its effect on central blood volume remains unknown.
Does the donation of 900 mL of blood reduce central blood volume in healthy men compared to sham phlebotomy?
RCT (n=21)
Single-blind
Randomized crossover
Does the donation of 900 mL of blood reduce central blood volume in healthy men compared to sham phlebotomy?
Donation of 900 mL of blood in healthy semi-recumbent men does not compromise central blood volume as measured by thoracic electrical impedance and plasma proANP, despite a modest decrease in stroke volume.
No takes yet. Share an insight, caveat, or question.
900 mL donation does not reduce CBV in healthy men; leaves open vasovagal risk mechanisms and donor safety in larger cohorts.
Gybel‐Brask et al. (2020) conducted an RCT in Healthy (n=21). Blood donation vs. Sham phlebotomy was evaluated on Changes in central blood volume estimated by proANP and thoracic electrical impedance. Donation of 900 mL of blood in healthy semi-recumbent men did not significantly affect central blood volume measured by thoracic electrical impedance and plasma proANP compared to sham donation.
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