November 1, 2014Genes & DevelopmentOpen Access

Target RNA capture and cleavage by the Cmr type III-B CRISPR–Cas effector complex

Q: What is the clinical evidence from this study?

Study design: Other. Intervention: Pyrococcus furiosus Cmr complexes. Primary outcome: Target RNA capture and cleavage.

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Key result

Reconstituted Pyrococcus furiosus Cmr complexes cleave target RNAs at 6-nucleotide intervals, with specific Cmr proteins playing critical roles in crRNA interaction and target RNA capture.

Authors

CHCaryn HaleRockefeller University ACAlexis CocozakiFlorida State University HLHong LiVan Andel Institute

Discussion

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Implication

Advances mechanistic models of CRISPR RNA targeting; leaves open translation to therapeutic applications.

PICO

Intervention / Comparator

Pyrococcus furiosus Cmr complexes

Primary Outcome

Target RNA capture and cleavage

Cite This Study

Hale et al. (2014) studied this question. Pyrococcus furiosus Cmr complexes was evaluated on Target RNA capture and cleavage. Reconstituted Pyrococcus furiosus Cmr complexes cleave target RNAs at 6-nucleotide intervals, with specific Cmr proteins playing critical roles in crRNA interaction and target RNA capture.

synapsesocial.com/papers/6a9ae6f12e5fc8ba907bc11f https://doi.org/10.1101/gad.250712.114

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Target RNA capture and cleavage by the Cmr type III-B CRISPR–Cas effector complex

Discussion

Member takes

Implication

PICO

Cite This Study

Target RNA capture and cleavage by the Cmr type III-B CRISPR–Cas effector complex

Discussion

Member takes

Implication

PICO

Cite This Study

Also Consider

Also Consider