What question did this study set out to answer?

Synthesize a photoreactive poly(ethylene glycol) derivative and evaluate its efficacy in preventing surface-induced platelet adhesion and activation on silane-coated glass.

March 1, 1992Journal of Biomedical Materials Research

Synthesis of photoreactive poly(ethylene glycol) and its application to the prevention of surface‐induced platelet activation

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Authors

YTYin‐Chao TsengBoehringer Ingelheim (Taiwan)KPK. ParkPurdue University West Lafayette

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Implication

In vitro study demonstrates complete prevention of platelet activation on modified glass, suggesting photoreactive polymer grafting improves blood-contacting biomaterials.

Key Points

Synthesize a photoreactive poly(ethylene glycol) derivative and evaluate its efficacy in preventing surface-induced platelet adhesion and activation on silane-coated glass.
Synthesized 4-azido-2-nitrophenyl poly(ethylene glycol) (ANP-PEG) by reacting 4-fluoro-3-nitrophenyl azide with the sodium salt of PEG, verified by 1H-NMR, IR, and UV spectroscopy.
Grafted ANP-PEG onto dimethyldichlorosilane-coated glass via UV photolysis without surface premodification across varying adsorption times, polymer concentrations, and irradiation durations.
Characterized surface free energies, PEG grafting density via ESCA, and platelet adhesion and activation by measuring adherent cell count and spread surface area.
Maximum PEG grafting efficiency required ANP-PEG pre-adsorption onto the silanized glass surface for at least 12 hours prior to UV irradiation.
No platelets adhered to grafted glass when the bulk ANP-PEG concentration in the adsorption solution remained between 1 mg/mL and 10 mg/mL.
Platelet activation increased progressively above 10 mg/mL ANP-PEG, reaching maximal activation at a concentration of 30 mg/mL.

Cite This Study

Tseng et al. (1992) studied this question.

synapsesocial.com/papers/6a9ae9835cd37f19ec7bc3cb https://doi.org/10.1002/jbm.820260308

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Implication

In vitro study demonstrates complete prevention of platelet activation on modified glass, suggesting photoreactive polymer grafting improves blood-contacting biomaterials.

Synthesis of photoreactive poly(ethylene glycol) and its application to the prevention of surface‐induced platelet activation

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Implication

Key Points

Cite This Study

Synthesis of photoreactive poly(ethylene glycol) and its application to the prevention of surface‐induced platelet activation

Discussion

Member takes

Implication

Key Points

Cite This Study

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