Patients with acromegaly have an increased risk of colorectal neoplasia and should undergo regular colonoscopic screening starting at age 40.
Supports colonoscopic screening from age 40 in acromegaly; extends IGF-1 as a risk marker for colorectal neoplasia guidelines.
cromegaly is characterised by excessive levels of circulating growth hormone and its tissue mediator, IGF-1. Before effective treatment and lowering of growth hormone and IGF-1 the majority of patients with the disease died by the aged of 60 years. 1 2 This was largely attributable to diabetes mellitus and cardiovascular and cerebrovascular diseases. ] That this increased risk might be related to serum growth hormone and/or IGF-1 levels is supported by recent epidemiological studies in the non-acromegalic population that have demonstrated an association between serum IGF-1 and the risk of colorectal cancer. 21 22 v13 www.gutjnl.com
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Jenkins et al. (2002) conducted a review in Acromegaly. Colorectal cancer screening was evaluated. Elevated serum IGF-1 levels are associated with an increased risk of colorectal cancer, supporting the rationale for screening guidelines in patients with acromegaly.
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