Acromegaly and Cancer

Editorials1 November 1984Acromegaly and CancerIRWIN KLEIN, M.D.IRWIN KLEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-5-706 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAcromegaly is an uncommon disease characterized clinically by enlargement of the acral parts, coarse facial features, and visceromegaly. In most patients the disorder arises from a tumor (adenoma) of the anterior pituitary gland that secretes excessive amounts of growth hormone, causing increased levels in serum (1). Because the disease is infrequent, its epidemiology is not well documented. Although 300 new cases are estimated to occur per year in the United States (1), a recent study has suggested that this figure should be closer to 900 (2). Part of the difficulty in assessing incidence rates is the wide variability in the...References1. CHRISTYWARREN NM. Disease syndromes of the hypothalamus and anterior pituitary. In: DEGROOT LJ, ed. Endocrinology. New York: Grune & Stranton; 1979:237. Google Scholar2. ALEXANDERAPPLETONHALLROSSWILKINSON LDRWR. Epidemiology of acromegaly in the Newcastle region. Clin Endocrinol (Oxf). 1980;12:71-9. CrossrefMedlineGoogle Scholar3. PEARSONARAFAHBRODKEY OBJ. Management of acromegaly [Editorial]. Ann Intern Med. 1981;95:225-6. LinkGoogle Scholar4. WRIGHTHILLLOWYFRASER ADCT. Mortality in acromegaly. Q J Med. 1970;39:1-16. MedlineGoogle Scholar5. ITUARTEPETRINIHERSHMAN EJJ. Acromegaly and colon cancer. Ann Intern Med. 1984;101:627-8. LinkGoogle Scholar6. KLEINPARVEENGAVALERVANTHIEL IGJD. Colonic polyps in patients with acromegaly. Ann Intern Med. 1982;97:27-30. LinkGoogle Scholar7. CLEMMONSVAN WYKRIDGWAYKLIMANKJELLBERGUNDERWOOD DJEBRL. Evaluation of acromegaly by radioimmunoassay of somatomedin-C. N Engl J Med. 1979;301:1138-42. CrossrefMedlineGoogle Scholar8. LEAVITTKLEINKENDRICKSGAVALERVANTHIEL JIFJD. Skin tags: a cutaneous marker for colonic polyps. Ann Intern Med. 1983;98:928-30. LinkGoogle Scholar9. CLEMMONSVAN WYK DJ. Somatomedin-C and platelet-derived growth factor stimulate human fibroblast replication. J Cell Physiol. 1981;106:361-7. CrossrefMedlineGoogle Scholar10. DAUGHADAYPHILLIPSMUELLER WLM. The effects of insulin and growth hormone on the release of somatomedin by the isolated rat liver. Endocrinology. 1976;98:1214-9. CrossrefMedlineGoogle Scholar11. RATNERHARE RJ. Association of acromegaly and chondrosarcoma. South Med J. 1983;76:1181-2. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe role of colonoscopic screening in acromegaly revisited: review of current literature and practice guidelinesAcromegaly and CancerColorectal neoplasia in acromegaly*Risk of colorectal neoplasia in acromegaly: an independent view*LiteraturInsulin-Like Growth Factor I and the Development of Colorectal Neoplasia in Acromegaly*Canine mammary growth hormone gene transcription initiates at the pituitary-specific start site in the absence of Pit-1Cancer in AcromegalyAcromegaly and Non-Hodgkin’s LymphomaGrowth hormone treatment in infertility: A short reviewPseudomyxoma peritonei et ovarii associated with sequential ovarian and appendicular tumors and acromegalyCOLON CANCER AND POLYPS IN ACROMEGALY: INCREASED RISK ASSOCIATED WITH FAMILY HISTORY OF COLON CANCEREpidemiology and Long-term Survival in Acromegaly: A Study of 166 Cases Diagnosed between 1955 and 1984Hereditary colon cancer syndromes: polyposis and nonpolyposis (Lynch syndromes I & II) variants 1 November 1984Volume 101, Issue 5Page: 706-707KeywordsAcromegalyAdenomasEpidemiologyGrowth hormonePituitary gland Issue Published: 1 November 1984 PDF downloadLoading ...