Stable Longitudinal Quality of Life in the SERVE Trial Among Adults With Transposition of the Great Arteries and a Systemic Right Ventricle

Figures

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  Figure 1. Flowchart of participants in the SERVE study. ccTGA, congenitally corrected transposition of the great arteries; d-TGA, dextro–transposition of the great arteries after atrial switch operation; FU, follow-up.

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  Figure 2. LAS scores and their changes over the 3-year follow-up in the intervention and placebo groups. The points indicate mean values, and the bars represent the standard deviation. Sample sizes for baseline, 1 year, and 3 years are n = 100, 92, and 83 for the overall cohort, n = 51, 45, and 41 for tadalafil, and n = 49, 47, and 42 for placebo, respectively. LAS, Linear Analog Scale; QoL, quality of life.

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  Figure 3. Variation of the LAS scores over the 3-year follow-up in subgroups according to the original anatomy and to the age category. Each line represents a single patient. ccTGA, congenitally corrected transposition of the great arteries; d-TGA, dextro–transposition of the great arteries; LAS, Linear Analog Scale.

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  Figure 4. Regression analysis performed to investigate the role of GSE as a predictor of QoL. (A) Shows the regression line for GSE and LAS score; (B) shows the regression line for GSE and SWLS score. A linear correlation is shown according to which higher GSE values predict a higher QoL level. The β coefficient indicates the slope of the curve, the r value indicates the strength of the linear relationship between the 2 studied variables, and the r2 value indicates the proportion of the QoL variation that is predictable from the GSE. The points indicate the values recorded in the single patients. The sample size is n = 100 for each of panels (A) and (B). GSE, General Self-Efficacy Questionnaire; LAS, Linear Analog Scale; QoL, quality of life; SWLS, Satisfaction with Life Scale.