Key result
Peripherally acting mu-opioid receptor antagonists, such as methylnaltrexone and alvimopan, are being investigated to mitigate opioid-induced gastrointestinal delays and manage postoperative ileus.
Why the study?
Do peripherally acting mu-opioid receptor antagonists accelerate the recovery of gastrointestinal function in patients with postoperative ileus?
Do peripherally acting mu-opioid receptor antagonists accelerate the recovery of gastrointestinal function in patients with postoperative ileus?
Peripherally acting mu-opioid receptor antagonists represent a potential multimodal approach to mitigate opioid-induced gastrointestinal delays and accelerate bowel recovery after surgery.
No takes yet. Share an insight, caveat, or question.
Remains under investigation for postoperative ileus; leaves open acceleration of GI recovery in routine practice.
Viscusi et al. (2009) conducted a review in Postoperative ileus. Peripherally acting mu-opioid receptor (PAM-OR) antagonists (methylnaltrexone and alvimopan) was evaluated. Peripherally acting mu-opioid receptor antagonists, such as methylnaltrexone and alvimopan, are being investigated to mitigate opioid-induced gastrointestinal delays and manage postoperative ileus.
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