Key result
Stepwise increasing hypoxia decreased the PEP/LVET-ratio and increased 1/PEP2 in dogs, with significant changes observed only when arterial oxygen tension fell below 40 mmHg.
Why the study?
Does stepwise increasing hypoxia alter systolic time intervals in mongrel dogs?
Does stepwise increasing hypoxia alter systolic time intervals in mongrel dogs?
Stepwise increasing hypoxia stimulates cardiac function as measured by systolic time intervals, with significant changes occurring at PaO2 < 40 mmHg.
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Severe hypoxia may alter canine systolic time intervals; leaves open translation to human monitoring or clinical decision-making.
Rasmussen et al. (1975) studied Hypoxia (n=7). Stepwise increasing hypoxia vs. Prehypoxic values was evaluated on Systolic time intervals (1/PEP2 and PEP/LVET-ratio). Stepwise increasing hypoxia decreased the PEP/LVET-ratio and increased 1/PEP2 in dogs, with significant changes observed only when arterial oxygen tension fell below 40 mmHg.
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