Key result
In calves supported by a biventricular assist device, cardiac output increased from 11.1 to 13.1 L/min and heart rate from 99 to 114 bpm during exercise, while pump flows remained unchanged.
Population
2 calves implanted with the Baylor Gyro PI 710 biventricular assist device in a biventricular bypass fashion…
Design
Preclinical
Follow-up
10 days convalescence prior to exercise
Authors
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Fixed-flow biventricular assist devices may limit exercise hemodynamics; hypothesis-generating for adaptive servo-control systems before clinical translation.
In a calf model of biventricular assist device support, fixed-rate pump flows do not increase during exercise, indicating the need for a servo control system to accommodate physical activity.
Linneweber et al. (2001) studied Biventricular assistance (n=2). Baylor Gyro PI 710 BVAD vs. Rest (baseline) was evaluated on Hemodynamic exercise response (cardiac output and heart rate). In calves supported by a biventricular assist device, cardiac output increased from 11.1 to 13.1 L/min and heart rate from 99 to 114 bpm during exercise, while pump flows remained unchanged.
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