Key result
In 2 calves, the implantable centrifugal blood pump with a recirculating purge system demonstrated trouble-free continuous function over 6 months with plasma free Hb levels <15 mg/dl.
A newly developed implantable centrifugal blood pump with a Cool-Seal system demonstrated excellent durability and low hemolysis in preclinical calf models over 6 months.
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Preclinical durability supports advancing the Cool-Seal pump to first-in-human testing; leaves open questions of long-term safety and efficacy.
Yamazaki et al. (1998) studied this question. Implantable centrifugal blood pump with a recirculating purge system (Cool-Seal System) was evaluated on Pump function and hemolysis. In 2 calves, the implantable centrifugal blood pump with a recirculating purge system demonstrated trouble-free continuous function over 6 months with plasma free Hb levels <15 mg/dl.
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