Key result
Very high multimorbidity on the electronic Multimorbidity Frailty Index was significantly associated with increased in-hospital mortality (HR 3.10; 95% CI 1.28-7.51) in older hospitalized patients.
Why the study?
This study evaluated the ability of an electronic Multimorbidity Frailty Index, incorporating 35 chronic conditions from electronic medical record data, to predict clinical outcomes in hospitalized older adults.
Does the electronic Multimorbidity Frailty Index predict clinical outcomes in hospitalized older adults?
Population
1491 patients aged ≥60 years admitted to an acute care hospital
Comparison
Moderate, high, and very high multimorbidity categories vs no or mild multimorbidity
Design
Exploratory observational cohort study
Authors
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May identify high-risk older inpatients; leaves open prospective validation of the electronic index.
Cohort (n=1,491)
Does the electronic Multimorbidity Frailty Index predict clinical outcomes in hospitalized older adults?
Hazard Ratio: 3.1 (95% CI 1.28–7.51)
The electronic Multimorbidity Frailty Index effectively predicts in-hospital mortality, functional recovery, and discharge destination in older hospitalized adults.
Toyoshima et al. (2025) conducted a cohort in hospitalized older adults (n=1,491). Very high multimorbidity (≥10 conditions on the electronic Multimorbidity Frailty Index) vs. No or mild multimorbidity (0-2 conditions) was evaluated on in-hospital mortality (HR 3.10, 95% CI 1.28-7.51). Very high multimorbidity on the electronic Multimorbidity Frailty Index was significantly associated with increased in-hospital mortality (HR 3.10; 95% CI 1.28-7.51) in older hospitalized patients.
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