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It has been reported that some kind of virus infection may participate in causing type 1 diabetes mellitus (insulin-dependent). However, no detailed clarification of the pathogenesis of this virus induced diabetes mellitus has been made. Craighead and McLanel1 described that the mice which was infected with M variant of encephalomyocarditis (EMC) virus may develop diabetes mellitus-like changes which were associated with insulitis and degranulation or destruction of 8 cells of the islets of the pancreas . Virus-induced diabetes mellitus in experimental animals attracts much attention from investigators as it may serve as an important model for studying the pathogenesis , pathological changes, and course of human diabetes mellitus.
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Shichinohe et al. (1987) studied this question.
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