Key result
Culturing differentiated chicken granulosa cells on intact or solubilized basal lamina significantly suppressed a Ca2+-dependent inward Cl- current compared to control cells.
Homologous basal lamina modulates a Ca(2+)-dependent Cl(-) current in differentiated granulosa cells, providing a partial explanation for its effects on metabolic functions.
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No clinical implications yet; leaves open whether basal lamina modulates Cl- currents in mammalian granulosa cells.
Qin et al. (2002) studied this question. Basal lamina (intact or solubilized) vs. Control cells was evaluated on Membrane currents (inward Cl- current). Culturing differentiated chicken granulosa cells on intact or solubilized basal lamina significantly suppressed a Ca2+-dependent inward Cl- current compared to control cells.
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