Key result
Specific 125I-endothelin-1 binding sites are highly concentrated in specific regions of the rat brain and porcine spinal cord, suggesting ET-1 may act as a neuropeptide.
The study demonstrates the presence of specific endothelin-1 binding sites in the central nervous system, suggesting ET-1 may act as a neuropeptide.
The quantitative receptor autoradiographic method we used revealed that specific 125I-endothelin-1 (125I-ET-1) binding sites are highly concentrated in the choroid plexus (ChP), subfornical organ (SFO), lacunosum molecular layer of the hippocampus (LMol) and granular layer of the cerebellum (GC) of the rat brain. High densities of the binding sites were also observed in the laminae I-III and intermediolateral nucleus of the porcine spinal cord. 125I-ET-1 bound to the rat ChP and LMol with a high-affinity and to the SFO and GC with a low-affinity. The possibility that ET-1 acts as a neuropeptide within the central nervous system by interacting with specific receptors would have to be considered.
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Niwa et al. (1991) studied this question. 125I-endothelin-1 was evaluated on Specific 125I-ET-1 binding sites concentration and affinity. Specific 125I-endothelin-1 binding sites are highly concentrated in specific regions of the rat brain and porcine spinal cord, suggesting ET-1 may act as a neuropeptide.
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