Key result
Randomized clinical trials provide the best evidence but have serious limitations, including unsuitability for certain situations, difficulty in subgroup analysis, and publication bias.
Design
Editorial
Authors
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Randomized clinical trials, while providing the best evidence, have serious limitations including unsuitability for certain clinical situations, difficulty in subgroup analysis, extrapolation issues, and publication bias.
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Desmond G. Julian (2003) reported an editorial. Randomized clinical trials provide the best evidence but have serious limitations, including unsuitability for certain situations, difficulty in subgroup analysis, and publication bias.
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