Answers are grounded in this paper and cite their sources.
// Nan Cui 1, 2 , Wen-Ting Yang 1, 3 , Peng-Sheng Zheng 1, 3 1 Department of Reproductive Medicine, First Affiliated Hospital, Xi’an Jiaotong University Medical School, Xi’an, The People’s Republic of China 2 Department of Biochemistry and Molecular Biology, Xi’an Jiaotong University Medical School, Xi’an, The People’s Republic of China 3 Section of Cancer Stem Cell Research, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of The People's Republic of China, Xi'an, The People's Republic of China Correspondence to: Peng-Sheng Zheng, email: zpsheng@mail.xjtu.edu.cn Keywords: Slug, Akt1, Wnt/β-catenin, cervical cancer, proliferation Received: January 05, 2016 Accepted: March 14, 2016 Published: March 28, 2016 ABSTRACT Slug (Snai2) has been demonstrated to act as an oncogene or tumor suppressor in different human cancers, but the function of Slug in cervical cancer remains poorly understood. In this study, we demonstrated that Slug could suppress the proliferation of cervical cancer cells in vitro and tumor formation in vivo . Further experiments found that Slug could trans-suppress the expression of Akt1/p-Akt1 by binding to E-box motifs in the promoter of the Akt1 gene and then inhibit the cell proliferation and tumor formation of cervical cancer cells by up-regulating p21/p27 and/or down-regulating the activity of the Wnt/β-catenin signaling pathway. Therefore, Slug acts as a tumor suppressor during cervical carcinogenesis.
No takes yet. Share an insight, caveat, or question.
Cui et al. (2016) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: